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Electroformation of Giant Vesicles from an Inverse Phase Precursor

Mertins O., da Silveira N.P., Pohlmann A. R., Schroder A.P., Marques C.M.

Thursday 25 June 2009, by mcube

We discuss a simple modification of the well-known method of giant vesicle electroformation that allows for a direct addition of water-soluble species to the phospholipid bilayers. Using this modified method, we prepare phospholipid vesicles decorated with chitosan, a water-soluble polysaccharide currently investigated for potential pharmacological applications. We find that the method allows this polysaccharide with primary amino groups on every glucose subunit to be tightly bound to the membrane, rather than simply being encapsulated.