EDEM is a reserach project led by A. Stocco in collaboration with Ali Abou-Hassan’s Team funded by ANR. EDEM aims at understanding and controlling particle engulfment and penetration in membranes using a biomimetic approach based on artificial self-propelling Janus particles interacting with giant unilamellar vesicles made of lipid bilayers acting as cell like compartments.
Objectives EDEM project is intended to:
- (1) engineer (using microfluidics) a new generation of multifunctional magnetic and plasmonic Janus hybrid microparticles which can be easily tracked by videomicroscopy, manipulated magnetically and are able to self-propel by light;
- (2) to study in a biomimetic approach the interaction of such particles with GUV membranes to control the particle engulfment by the membrane via the particle morphology, adhesion strength, and the membrane spontaneous curvature;
- (3) and finally characterize the interaction of these self-propelled Janus microparticles with lipid bilayer membranes. Dedicated experiments at the single particle level to achieve a fine control on particle penetration, vesicle transportation and membrane disruption will be carried out during this project.
- Rotational and translational drags of a Janus particle close to a wall and a lipid membrane
Vaibhav Sharma, Florent Fessler, Fabrice Thalmann, Carlos M Marques and Antonio Stocco
Journal of Colloid and Interface Science, Volume 652, Pages 2159-2166 (2023)
- Entry of microparticles into giant lipid vesicles by optical tweezers
Florent Fessler, Vaibhav Sharma, Pierre Muller, and Antonio Stocco
Phys. Rev. E 107, L052601
- Driven Engulfment of Janus Particles by Giant Vesicles in and out of Thermal Equilibrium
V Sharma, CM Marques, A Stocco
Nanomaterials 12 (9), 1434